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SARS-CoV-2 antibodies in breastmilk after COVID-19 infection versus after COVID-19 vaccination

SARS-CoV-2 antibodies in breastmilk after COVID-19 infection versus after COVID-19 vaccination

This article was published on
November 10, 2021

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A study published in JAMA Paediatrics looks at breastmilk antibody induction, persistence, and neutralizing capacity after SARS-CoV-2 infection vs after mRNA vaccination.

A study published in JAMA Paediatrics looks at breastmilk antibody induction, persistence, and neutralizing capacity after SARS-CoV-2 infection vs after mRNA vaccination.

Publication

Association of Human Milk Antibody Induction, Persistence, and Neutralizing Capacity With SARS-CoV-2 Infection vs mRNA Vaccination

Not peer-reviewed
This work has not been scrutinised by independent experts, or the story does not contain research data to review (for example an opinion piece). If you are reporting on research that has yet to go through peer-review (eg. conference abstracts and preprints) be aware that the findings can change during the peer review process
Peer-reviewed
This work was reviewed and scrutinised by relevant independent experts.

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Expert Comments: 

Prof Richard Tedder

My concern with this extensive, useful and thought-provoking paper is that they have used an indirect assay which is simply not the assay format of choice for a non-blood analytes such as the fluid from the breast milk.  Their proof of concept was an experiment to show the IgA such as one would find in fractionated maternal milk was detectable by their indirect immunoassay.  What is not clear is the sensitivity overall and specificity overall of this approach.  Nevertheless it is an interesting paper and their choice of determining antibody to the receptor binding domain is appropriate.

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