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German preprint giving theory about why blood clots might rarely occur after vector-based COVID-19 vaccines

This article was published on
May 27, 2021

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A preprint, an unpublished non-peer reviewed study, from researchers in Germany presents a theory for why vector-based COVID-19 vaccines, such as Oxford-AstraZeneca and Johnson & Johnson, may cause rare blood clots.

A preprint, an unpublished non-peer reviewed study, from researchers in Germany presents a theory for why vector-based COVID-19 vaccines, such as Oxford-AstraZeneca and Johnson & Johnson, may cause rare blood clots.

Publication

Vaccine-Induced Covid-19 Mimicry” Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines

Not peer-reviewed
This work has not been scrutinised by independent experts, or the story does not contain research data to review (for example an opinion piece). If you are reporting on research that has yet to go through peer-review (eg. conference abstracts and preprints) be aware that the findings can change during the peer review process
Peer-reviewed
This work was reviewed and scrutinised by relevant independent experts.

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Expert Comments: 

Prof Jonathan Ball

It’s a really interesting hypothesis, that errant processing of the delivered spike gene results in the production of a truncated spike protein, which gets secreted from the cell, potentially triggering blood clotting events.

The data certainly highlights that production of this truncated spike may well occur, but it stops short of providing a concrete link with promotion of blood clotting.  Nevertheless, it is certainly something worth investigating further.

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